BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Research Seminars//NONSGML Events//EN
CALSCALE:GREGORIAN
X-ORIGINAL-URL:https://calendar.med.wustl.edu/calendar/list/
X-WR-CALDESC:Research Seminars - Events
BEGIN:VEVENT
UID:20230223T1559Z-1677167992.0261-EO-30673-1@172.23.128.18
STATUS:CONFIRMED
DTSTAMP:20260619T175152Z
CREATED:20230223T153119Z
LAST-MODIFIED:20230321T141252Z
DTSTART;TZID=America/Chicago:20230321T130000
DTEND;TZID=America/Chicago:20230321T140000
SUMMARY: Cell Biology & Physiology Seminar Series (Hybrid)
DESCRIPTION: IN-PERSON ONLY EVENT The seminar will take place in the McDonn
 ell Sciences Building\, Room 423. “New transcriptomic and imaging tools to 
 track trajectories of aging and disease” Abstract:  We are in a biological 
 imaging and measurement revolution as tools are rapidly advancing our abili
 ty to measure proteins at the nanometer-scale\, cells at the micron-scale\,
  tissues […]
X-ALT-DESC;FMTTYPE=text/html: <p><strong>IN-PERSON ONLY EVENT</strong><br /
 ><strong>The seminar will take place in the McDonnell Sciences Building\, R
 oom 423.</strong></p><h2>"New transcriptomic and imaging tools to track tra
 jectories of aging and disease"</h2><p>[caption id="attachment_30674" align
 ="alignnone" width="149"]<img class=" wp-image-30674" src="https://calendar
 .med.wustl.edu/app/uploads/2023/02/marti-ed_HertzFellow.jpg" alt="" width="
 149" height="188" /> G. Edward Marti\, Ph.D.[/caption]</p><p><strong>Abstra
 ct:</strong>  We are in a biological imaging and measurement revolution as 
 tools are rapidly advancing our ability to measure proteins at the nanomete
 r-scale\, cells at the micron-scale\, tissues at the millimeter-scale and b
 eyond. There is an unmet need to improve longitudinal measurements of molec
 ular and cellular changes inside living animals and witness key events in a
 n organism's response to aging and disease progression. I will present our 
 efforts to study changes in cellular heterogeneity in aging mice with singl
 e-cell transcriptomics\, and to enhance the time resolution of single-molec
 ule experiments with novel imaging techniques.</p><p>Single-cell transcript
 omic atlases are teaching us that a "cell type" is really a heterogenous mi
 xture of cells with a continuum of expression\, yet it has long been contes
 ted how\, or if\, that heterogeneity changes with age. We developed a quant
 itative model of the measurement process from which we can identify genes w
 ith changing levels of biological noise from young adult to elderly mice. W
 e find that genes involved in metabolism (specifically\, oxidative phosphor
 ylation) shows a ubiquitous decrease in noise and heterogeneity with age ac
 ross disparate cell types and tissues.</p><p>Super-resolution imaging of br
 ight nanoparticles enables us to track individual dynein molecular motors w
 ith a resolution of several nanometers and milliseconds. We are constructin
 g a next-generation microscope towards angstrom localization in tens of mic
 roseconds to resolve record-fast dynamics of individual molecular motors an
 d proteins. Furthermore\, we are building a multimolecular platform with ta
 rgeted microbubbles to image cellular changes by centimeters inside a livin
 g animal for days or weeks using ultrasound imaging.</p>
CATEGORIES:Faculty Candidate Seminar,Invited External Speakers,Seminars / Lectures
ORGANIZER;CN="Terese":MAILTO:tereseh@wustl.edu
URL;VALUE=URI:https://calendar.med.wustl.edu/calendar/event/30673/
END:VEVENT
BEGIN:VTIMEZONE
TZID:America/Chicago
BEGIN:DAYLIGHT
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
DTSTART:20230312T080000
TZNAME:CDT
END:DAYLIGHT
END:VTIMEZONE
END:VCALENDAR