BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Research Seminars//NONSGML Events//EN CALSCALE:GREGORIAN X-ORIGINAL-URL:https://calendar.med.wustl.edu/calendar/list/ X-WR-CALDESC:Research Seminars - Events BEGIN:VEVENT UID:20240827T1819Z-1724782760.0692-EO-31979-1@10.24.106.144 STATUS:CONFIRMED DTSTAMP:20260802T071202Z CREATED:20240827T180719Z LAST-MODIFIED:20241206T192721Z DTSTART;TZID=America/Chicago:20241217T130000 DTEND;TZID=America/Chicago:20241217T140000 SUMMARY: Cell Biology & Physiology Seminar Series DESCRIPTION: “Leveraging Whispering-Gallery-Mode Optical Resonators for Bio medical Applications: Ultrasensitive and Label-Free Detection of Nanopartic les and Cells” Optical sensors are at the forefront of advancements in biom edical research\, clinical diagnostics\, and environmental monitoring. Amon g the diverse sensing technologies\, whispering-gallery-mode (WGM) resonato rs have gained prominence for their unique ability to amplify interactions between light and biological targets. Like […] X-ALT-DESC;FMTTYPE=text/html:
"Leveraging Whispering-Gallery-Mo de Optical Resonators for Biomedical Applications: Ultrasensitive and Label -Free Detection of Nanoparticles and Cells"

[caption id="at tachment_32160" align="alignnone" width="251"] Lan Yang\, Ph.D.[/caption]

Optical sensors are at the forefront of advancements in biomedical research\, clinical diagnostics\, and environmental monitori ng. Among the diverse sensing technologies\, whispering-gallery-mode (WGM) resonators have gained prominence for their unique ability to amplify inter actions between light and biological targets. Like a whisper traveling alon g a circular wall\, photons in WGM resonators propagate along a curved surf ace. Ultra-high-quality (Q) optical WGM microresonators significantly enhan ce light-matter interactions\, presenting new opportunities for ultra-sensi tive and label-free detection of small objects\, such as nanoparticles\, mo lecules\, and cells\, in biomedical research. This seminar will explain how nanomaterial interactions with a high-Q WGM resonator can alter photon tra jectories and lifetimes\, offering precise and quantifiable measurements. G roundbreaking applications\, such as the detection and sizing of nanopartic les—including single virions—using ultra-sensitive\, self-referencing micro resonators and microlasers\, will be explored. Furthermore\, the seminar wi ll highlight how optical gains in microlasers can push detection limits bey ond conventional passive resonators. Innovative sensing strategies\, includ ing barcode technology leveraging collective responses of multiple resonanc es to enhance sensitivity and dynamic range of sensing measurement\, label- free detection via photoacoustic spectroscopy\, and AI-enhanced target clas sification\, will be discussed for their transformative potential in biomed ical sensing. The versatility of WGM sensors will be demonstrated through a probe-type configuration capable of scanning surfaces to collect resonance -enhanced Raman signals. In particular\, a WGM microprobe that enhances the sensitivity of commercial Surface-Enhanced Raman Spectroscopy (SERS) test papers will be presented\, demonstrating its potential for highly sensitive \, label-free molecular detection. The presentation will conclude with the introduction of a handheld sensing platform\, a compact evolution of tradit ional setups\, promising to expand the accessibility and applicability of W GM sensor technology.

CATEGORIES:Seminars / Lectures LOCATION:McDonnell Sciences Building\, 4th Floor\, Room 423 GEO:0.000000;0.000000 ORGANIZER;CN="Terese":MAILTO:tereseh@wustl.edu URL;VALUE=URI:https://calendar.med.wustl.edu/calendar/event/cell-biology-ph ysiology-seminar-series-106/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:STANDARD TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:20241103T070000 TZNAME:CST END:STANDARD END:VTIMEZONE END:VCALENDAR