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UID:20230209T2128Z-1675978133.0323-EO-30548-1@172.23.128.18
STATUS:CONFIRMED
DTSTAMP:20260724T115902Z
CREATED:20230209T212516Z
LAST-MODIFIED:20230209T212829Z
DTSTART;TZID=America/Chicago:20230314T130000
DTEND;TZID=America/Chicago:20230314T140000
SUMMARY: Cell Biology & Physiology Seminar Series
DESCRIPTION: “Designer immunity for cancer and beyond” Abstract:  My goal i
 s to unleash the therapeutic potential of our own immune system via synthet
 ic biology approach. Recently\, we have witnessed remarkable progress in ca
 ncer treatment that employs adoptive cell transfer of tumor-specific “kille
 r” T cells. However\, tumors impede the infiltration\, survival\, and funct
 ion of T cells\, rendering […]
X-ALT-DESC;FMTTYPE=text/html: <p>[caption id="attachment_30551" align="alig
 nnone" width="228"]<img class=" wp-image-30551" src="https://calendar.med.w
 ustl.edu/app/uploads/2023/02/Kay-Chung-4x5-1-300x376.jpg" alt="" width="228
 " height="286" /> H. Kay Chung\, Ph.D.[/caption]</p><h2>"Designer immunity 
 for cancer and beyond"</h2><p style="font-weight: 400\;"><strong>Abstract:<
 /strong>  My goal is to unleash the therapeutic potential of our own immune
  system via synthetic biology approach. Recently\, we have witnessed remark
 able progress in cancer treatment that employs adoptive cell transfer of tu
 mor-specific “killer” T cells. However\, tumors impede the infiltration\, s
 urvival\, and function of T cells\, rendering the beneficial effects of thi
 s approach transient. To address this hurdle\, I have been exploring T cell
  state programming. In the Susan Kaech laboratory at the Salk Institute\, I
  have identified transcription factors that enhance the memory and tumor-ki
 lling ability of T cells in an unbiased manner. I will discuss my multiomic
 s pipeline that predicts transcription factor activity as well as a multipl
 exed single-cell RNA sequencing approach that I have used for hit validatio
 n. I will also share how novel transcription factors\, Zscan20\, JDP2\, and
  Nfil3\, can be utilized for therapeutic purposes. In the second part of my
  talk\, I will discuss clinically applicable synthetic biology tools that I
  have developed during my Ph.D. training at Stanford University. They enabl
 e drug\, cell signal\, and light-dependent control of any protein for cell-
 /virus-based therapies. Leveraging these tools\, I will achieve an “ideal” 
 T cell state. More specifically\, I will combinatorially and context-depend
 ently regulate master transcription factors so that they can toggle between
  T cell states best suited for fighting cancer cells at a given time in a g
 iven environment. My synthetic biology approaches not only enable effective
  T cell programming but also serve as a safety feature. In short\, my desig
 ner cell state differentiation strategy allows us to fully capitalize on th
 e therapeutic potential of our immune system for cancer and beyond.</p><p><
 strong>Faculty Host:  Sheila Stewart\, Ph.D.</strong></p>
CATEGORIES:Faculty Candidate Seminar,Invited External Speakers,Seminars / Lectures
LOCATION:McDonnell Sciences Building\, 4th Floor\, Room 423
GEO:0.000000;0.000000
ORGANIZER;CN="Terese":MAILTO:tereseh@wustl.edu
URL;VALUE=URI:https://calendar.med.wustl.edu/calendar/event/cell-biology-ph
 ysiology-seminar-series-66/
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DTSTART:20230312T080000
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