Emil R . Unanue Professor\, Department of Pathology & Immunology
WashU Medic ine
Host: Dr. Jim Skeath
Talk Title: Peritoneal cavity macr ophages in mouse and humans – differentiation\, heterogeneity\, and roles i n disease
Abstract: In this seminar\, I will describe our work d efining the heterogeneity of resident macrophages in the body cavity\, begi nning with mouse and proceeding to work that compares mouse and human perit oneal macrophages\, taking into account the fluid and tissue compartments o f the unique peritoneal space that are both rich in macrophages. This resea rch involving single cell RNA profiing in both species\, profiling and gene tic manipulation in mice\, use of humanized mice and human samples\, identi fies key similarities and key differences between the two species. Findings will be discussed in relation to the possibility that the results might im pact approaches to peritoneal conditions as varied as peritoneal adhesions\ , endometriosis\, peritoneal tumors and metastases\, and spread of infectio n in the cavity.
CATEGORIES:Seminars / Lectures LOCATION:Holden Auditorium\, Farrell Learning &\; Teaching Center GEO:38.635073;-90.262286 ORGANIZER;CN="Michelle":MAILTO:gibbsm@wustl.edu URL;VALUE=URI:https://calendar.med.wustl.edu/calendar/event/genetics-semina r-series-gwen-randolph-phd/ END:VEVENT BEGIN:VTIMEZONE TZID:America/Chicago BEGIN:STANDARD TZOFFSETFROM:-0500 TZOFFSETTO:-0600 DTSTART:20251102T070000 TZNAME:CST END:STANDARD END:VTIMEZONE END:VCALENDAR