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UID:20240820T1658Z-1724173132.5011-EO-31926-1@10.24.106.144
STATUS:CONFIRMED
DTSTAMP:20260414T052704Z
CREATED:20240820T165758Z
LAST-MODIFIED:20240916T171102Z
DTSTART;TZID=America/Chicago:20241003T120000
DTEND;TZID=America/Chicago:20241003T130000
SUMMARY: Genetics Seminar Series – Inaugural Stormo Lectureship
DESCRIPTION: Mapping and Modeling Transcriptional Regulatory Networks Hoste
 d by:  Dr. Guoyan Zhao and Genetics students & postdocs In-person only:  Co
 nnor Auditorium (FLTC) Abstract: Transcription factor (TF) binding location
 s can be mapped using methods such as ChIP-Seq or Calling Cards and the fun
 ctional targets of a TF can be identified by perturbing the TF and measurin
 g changes in […]
X-ALT-DESC;FMTTYPE=text/html: <h2><em><strong>Mapping and Modeling Transcri
 ptional Regulatory Networks</strong></em></h2><p><strong>Hosted by:</strong
 >  Dr. Guoyan Zhao and Genetics students & postdocs<br /><strong>In-person 
 only: </strong> Connor Auditorium (FLTC)</p><p><strong>Abstract: </strong>T
 ranscription factor (TF) binding locations can be mapped using methods such
  as ChIP-Seq or Calling Cards and the functional targets of a TF can be ide
 ntified by perturbing the TF and measuring changes in gene expression. Howe
 ver\, it has long been known\, across many organisms and datasets\, that th
 e agreement between binding locations and perturbation responses is extreme
 ly poor. Identifying the direct\, functional targets of TFs is essential fo
 r understanding how DNA sequence gives rise to phenotypes. In this talk\, I
  will present an integrated analysis of multiple datasets\, including new C
 alling Cards data\, to shed light on this discrepancy and propose strategie
 s for predicting perturbation responses from TF binding locations.</p>
CATEGORIES:Seminars / Lectures
LOCATION:Connor Auditorium\, Farrell Learning and Teaching Center
GEO:38.635021;-90.263078
ORGANIZER;CN="Michelle":MAILTO:gibbsm@wustl.edu
URL;VALUE=URI:https://calendar.med.wustl.edu/calendar/event/genetics-semina
 r-series-inaugural-stormo-lectureship/
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DTSTART:20240310T080000
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