Karen Miga, PhD
Assistant Professor
Department of Biomolecular Engineering
University of California, Santa Cruz

Department of Genetics

Expanding studies of global genomic diversity with complete, telomere-to-telomere (T2T) assembly of diploid genomes

Hosted by:  Dr. Ting Wang
In-person only:  Connor Auditorium (FLTC)

Talk abstract:  The Telomere-to-Telomere (T2T) Consortium has finished the first truly complete human genome, representing gapless assemblies for all 22 autosomes plus Chromosomes X and Y, corrects numerous errors, and introduces nearly 200 million bp of novel sequence. Here I will discuss new methods to automate T2T diploid chromosome assembly and quality assessment, and the importance of T2T references in establishing a new human pangenome, and how such resources can drive new genetic and epigenetic discoveries across hundreds of diverse human haplotypes.