Yidan Sun, PhD
Sr. Bioinformatics Scientist & Project Lead
Max Planck Institute of Immunobiology & Epigenetics

McDonnell Genome Institute, Department of Genetics, Center for Translational Bioinformatics (CTBI)

“Decoding allelic imbalance regulatory network with multi-omics and AI technologies”

Talk abstract:  By leveraging multi-omics and AI technologies, we first identified that the epigenetic regulator MSL2 plays a pivotal role in establishing enhancer-promoter interactions to mediate the transition from monoallelic to biallelic expression in haploinsufficient genes associated with neurological disorders. Furthermore, I developed a deep learning model, which predicts enhancer-promoter interactions from scATAC-seq datasets, revealing disruptions of enhancer interactions in both colorectal cancer and Alzheimer’s disease.