Gwendalyn J. Randolph, PhD
Emil R. Unanue Professor
Department of Pathology & Immunology
WashU Medicine

Department of Genetics

Gwendalyn J. Randolph, PhD

Emil R. Unanue Professor, Department of Pathology & Immunology

WashU Medicine

Host: Dr. Jim Skeath

Talk Title: Peritoneal cavity macrophages in mouse and humans – differentiation, heterogeneity, and roles in disease

Abstract: In this seminar, I will describe our work defining the heterogeneity of resident macrophages in the body cavity, beginning with mouse and proceeding to work that compares mouse and human peritoneal macrophages, taking into account the fluid and tissue compartments of the unique peritoneal space that are both rich in macrophages. This research involving single cell RNA profiing in both species, profiling and genetic manipulation in mice, use of humanized mice and human samples, identifies key similarities and key differences between the two species. Findings will be discussed in relation to the possibility that the results might impact approaches to peritoneal conditions as varied as peritoneal adhesions, endometriosis, peritoneal tumors and metastases, and spread of infection in the cavity.